The future of combination therapy in melanoma U. Keilholz says the combination treatment in melanoma comprises of combination of targeted agents or combination of targeted therapy and immunotherapy. The targeted therapy offers faster response, while immunotherapy works slow in induction phase, but provides more durable response. These facts translates into current thinking in treatment scenarios; furthermore, he elaborates perspective of studying the right therapy sequence. Video produced by the European Society for Medical Oncology (ESMO)